MTHFR: B12 (Hydroxocobalamin)

B12 (Hydroxocobalamin) has many important roles including proper functioning of the nervous system, and in the conversion of homocysteine into methionine. Chronic Fatigue Syndrome (CFS) and Fibromyalgia are two common conditions associated with Vitamin B12 deficiency as well.

If all is going well in your body, it should be made naturally with the help of your gut bacteria. Therefore you’re likely to see a deficiency in conditions where B12 cannot be properly absorbed in the gut. This is usually when supplementation is prescribed.

For deficiencies, it’s available as capsules, lozenges, a chewable tablet or prescribed as an injection (at home or in a clinic).

The methylation process converts hydroxocobalamin into methylcobalamin. This has an important role in keeping nerve cells less toxic – helping in many neurological disorders. (Hydroxocobalamin is a precursor to methylcobalamin and Vitamin B12.)

Hydroxocobalamin also converts homocysteine to methionine. So if we’re B12 deficient, homocysteine levels may rise. Homocysteine is considered toxic when it is too high, and will affect blood vessels as well as nerves in the body. Increased levels of homocysteine are also associated with other conditions such as stroke, Alzheimer’s, cardiovascular disorders and osteoporosis.

Taking Hydroxocobalamin helps Vitamin B12 levels, thereby reducing homocysteine in the body and reversing the side effects.

Btw, Chronic Fatigue Syndrome (CFS) and Fibromyalgia are two common conditions associated with Vitamin B12 deficiency. In both conditions, elevated levels of homocysteine persist due to low levels of Vitamin B12.

Start slowly on 2,000 mcc chewable tablets spread out throughout the day.


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