MTHFR: Histamine.

‘The causative factors for histamine intolerance are many:

  • Genetic susceptibility
  • Nutrient deficiencies (B12, folate, B6, B2, B1, Zn, Cu, C, methionine)
  • Nutrient excesses (histidine, protein excess in general)
  • Medications (antibiotics, antacids and even antihistamines (long term))
  • Nutrient demands (stress, anxiety, lack of sleep)
  • Hormonal insufficiciency (adrenal fatigue)
  • Hormonal excess (estrogen)
  • Lifestyle (excessive exercise, alcohol)
  • Diet (fermented foods, high protein intake, aged foods, leftovers, citrus, fish)
  • Environment (high pollen counts, dust mites)
  • Associated conditions (leaky gut, IBD, IBS)

In order to reduce histamine loads, I typically recommend these things right out of the gate:

Diet: no fermented foods, no leftovers, no citrus, only FRESH fish or no fish, no alcohol, no aged foods. This includes cheeses, wines and processed meats. Limit protein as protein provides histidine. Histidine transforms to histamine. Eat more fatty foods (healthy – like ghee) and whole grains (quinoa, wild rice). A more ketogenic diet would be great – but some cannot tolerate this (due to adrenal fatigue and electrolyte imbalance).

Lifestyle: sleep, reduce stress (huge), breathe (seriously), optimize exercise – don’t overdo it, laugh!, do things you love – don’t wait anymore.

Environment: new pillow, dust mite covers, clean the house, clean ducts, air purifiers, no air fresheners (dang things SUCK and are very nasty and contribute to histamine intolerance due to aldehydes), rip out carpet, install hardwood or tile, fresh air, drive with air recycle on whilst in traffic otherwise fresh air.

Mindset: positive, get it done attitude, empower, remove the ‘fix me’ mentality as it is the patient who must fix themselves and seek the right healthcare (which is NOT easy to do).’ Excerpt by Dr. Ben Lynch –…/…/


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